Many types of scaffolds such as films, nanofiber sheets, sponges, hydrogels, and composites were fabricated for muscle tissue engineering, and an optimal cellular environment for muscle cells’ attachment and proliferation is provided in the scaffolds by assigning essential components required for the muscle tissue regeneration. Polymeric scaffolds for tissue engineering play a role of framework to maintain the 3D tissue formation. Gilson Khang, in Tissue Engineering, 2022 Scaffold types
Scaffold meaning in biology skin#
Based on current findings, electrospinning of biopolymers may be expected to contribute to advanced designs for engineered human skin and to reduction in morbidity from skin wounds.ĭae Hoon Lee. With optimized structures and degradation rates, electrospun biopolymer scaffolds have been shown to increase mechanical strength and stability, reduce wound contraction and promote engraftment of epidermal tissue substitutes. Electrospinning of biopolymers offers advantages in precision of fabrication and versatility of composition compared to freeze-dried sponges. While the current model of CSS has distinct advantages, it is clear that alternative fabrication strategies may improve the quality and function of bioengineered skin. Cultured skin substitutes (CSS), consisting of autologous fibroblasts and keratinocytes on a biopolymer sponge, have been successfully used to treat full-thickness burns. Boyce, in Biomaterials for Treating Skin Loss, 2009 Abstract:īiopolymer scaffolds for tissue engineering allow cellular organization into tissue substitutes and can regulate development of connective tissue to minimize scarring. The silk scaffolds alone produced a fibrous tissue but, when seeded with adipogenic differentiated cells, maintained their adipogenic state with lipid-laden cells observed over time. In adipose tissue engineering, it has been applied as a scaffold for adipogenic differentiation of stem cells and subsequently implanted in rodent models. Silk is another naturally derived scaffold that is fibrous in nature and has high mechanical strength. So far, researchers have used it in combination with HA to form an injectable hydrogel or with PLGA to form a porous scaffold for adipose tissue engineering. Similar to alginate, chitosan is a natural polysaccharide that is isolated from chitin. To render alginate susceptible to degradation, an oxidized form of alginate was also investigated as well as combined collagen alginate microspheres to better mimic the native extracellular matrix environment. Adipogenic differentiated stem cells were encapsulated in alginate and implanted subcutaneously. Alginate is a natural polysaccharide derived from seaweed. Some examples of naturally derived biomaterials are alginate, silk, and chitosan. Scaffolds for tissue engineering can also be derived from natural sources and generally have high biocompatibility.
Iwen Wu, Jennifer Elisseeff, in Natural and Synthetic Biomedical Polymers, 2014 14.2.2 Naturally Derived Scaffolds
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